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Measures (via magnetic resonance spectroscopy) of improvement of maximal ATP production did not change significantly between baseline and four months in either group [ 2].
Scientists also believe that a buildup of mitochondria can lead to an increased risk of other diseases – like Parkinson’s and other age-related conditions. In fact, this can be an over-arching cause behind many age-related diseases – mitochondria problems. Urolithin Caused Lifespan to Increase by 45% Compared to a Control
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Great question. There's a lot of brands out there that call themselves science driven.We thought hard about how we are different to that. A few interventional studies have investigated the presence of urolithin metabolites after intake of dietary fruits (strawberry and raspberry) and nuts (walnuts) in different study populations [ 11, 12]. Investigators have also examined the association between different urolithin plasma profiles and health benefits, such as lowering cardiovascular risk in overweight populations [ 2, 13, 14]. However, there are limited data in large and diverse age groups in healthy adult populations describing the frequency and extent of people’s natural ability to convert ET and EA into UA such as after drinking a glass of pomegranate juice (PJ) or eating the recommended quantities of nuts and berries. As reported previously by NutraIngredients-USA, Amazentis has developed a method to deliver finely calibrated doses of urolithin A. Preliminary data published in Nature Medicine indicated that urolithin A may improve mitochondrial function by stimulating mitophagy, a process by which damaged mitochondria are recycled to permit a renewal with healthy mitochondria. Urolithin A (UA) is produced endogenously by human gut bacteria exposed to dietary polyphenolic compounds that include ellagic acid (EA) and ellagitannins (ET), such as punicalagin [ 1]. These polyphenolic precursors are found widely in fruits (pomegranate and certain berries) and nuts (walnuts and pecans). ET are converted to EA in the upper portion of the human gastrointestinal tract, and further metabolized by gut microflora in the large intestine into compounds known as urolithins, of which UA is among the most common [ 2, 3]. Individuals show large differences in urolithin production capacity due to variations in the microbiome responsible for ET metabolism [ 4]. Urolithins, including UA, are absorbed and conjugated in the liver and are subsequently excreted in urine and feces. Several studies have shown that UA and its two main detectable metabolites, UA glucuronide and UA sulfate, are the predominant urolithin forms in circulation [ 5, 6]. FL: This is a rapidly evolving space and there's a lot of ongoing scientific research. So I can't comment in absolute terms. What we do know is Mitopure is the only mitophagy inducer that has been taken into the clinic and has been shown to improve mitochondrial function and muscle strength in humans.
An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans. New research, published in JAMA Network Open, suggests that the supplement, urolithin A, may help improve or prolong muscle activity in people who are aging or who have diseases that make exercise difficult. HIGHLY DOSED: 1000mg pomegranate extract per daily dose of pomegranate fruit powder (600mg) and pomegranate peel extract (400mg) - rich in ellagic acid (40%) with high bioavailability Recipients of Urolithin A supplements in a 2022 Studyshowed increased markers of mitochondrial health and reduced muscular fatigue over sustained periods of exercise. Across both cohorts, two comparisons of muscle function were found to support the thesis, but two others did not: Don’t run out to the supermarket and buy pomegranate right away. The fruit itself doesn’t contain the miracle molecule.Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults” Urolithin A is a special molecule in pomegranates that, on its own, isn’t anything special. However, when you eat pomegranate, and that molecule encounters the microbes in your gut, it enables your muscle cells to protect themselves against of the major causes of aging. Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Felix AA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016;22:879–88.
To be eligible for inclusion, subjects needed to be in general good health defined as the absence of any chronic ailments and as determined by the study medical doctor, and to have given voluntary, written, informed consent to participate. Subjects also needed to be willing to consume the investigational products, complete screening questionnaires, and complete all clinic visits during the study. Subjects were excluded if they had presence of any chronic medical conditions and clinically significant abnormal laboratory results at screening. Individuals deemed to be cognitively impaired and unable to give informed consent were excluded as well. Women who were pregnant, breastfeeding, or planning to become pregnant during the course of the trial, and subjects who had taken antibiotics within the previous 30 days of the study screening, were also excluded. Subjects were instructed to follow their usual diet and exercise routine and to not consume any other dietary supplements that could interfere with the assessment of the study products for the duration of the study. Subjects completed a food-frequency questionnaire (FFQ) during the screening visit to assess their dietary intake. The FFQ used for this purpose was the DHQ-III [ 15]. Investigational products and randomization Your Health Goals: Your dosage may depend on your specific health objectives. For instance, if you’re aiming for muscle support or enhanced athletic performance, you might lean toward the higher end of the dosage range. Conversely, if you’re primarily interested in cellular health, a lower dose may suffice. Antioxidants: Some supplements include additional antioxidants like vitamin C or vitamin E to complement Urolithin A’s antioxidant properties. This can provide a synergistic effect for cellular protection. Toney AM, Fan R, Xian Y, Chaidez V, Ramer-Tait AE, Chung S, et al. a gut metabolite, improves insulin sensitivity through augmentation of mitochondrial function and biogenesis. Obes (Silver Spring). 2019;27:612–20.
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The gut microbiome has a profound impact on our overall well-being, from digestion to immunity. Urolithin A may promote a healthy gut by encouraging the growth of beneficial bacteria while suppressing harmful ones. This balance in the gut microbiome can lead to improved digestion, better nutrient absorption, and enhanced immune function. 7. Longevity and Aging Gracefully: The chief benefit of Urolithin A is its ability to aid the process known as mitophagy – the breaking down and removal of old, dysfunctional mitochondria cells.
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